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临床研究｜｜Clinical Articles              磁共振成像  2024年7月第15卷第7期  Chin J Magn Reson Imaging, Jul, 2024, Vol. 15, No. 7


           有代偿作用的功能网络连接重塑。                                      [4]  CUI  Y,  TANG  T  Y,  LU  C  Q,  et  al.  Insulin  resistance  and  cognitive
                                                                   impairment: Evidence from neuroimaging[J]. J Magn Reson Imaging,
           3.3 T2DM患者dFNC指标与临床指标的相关关系                              2022, 56(6): 1621-1649. DOI: 10.1002/jmri.28358.
                                                                [5]  高玉军, 孙杰, 郭鑫, 等 . 静息态脑功能磁共振成像在双相障碍辅助
               在相关性分析中，我们并未发现平均滞留时间、                               诊断和早期疗效预测中的研究进展[J]. 磁共振成像, 2023, 14(12):
           时间分数以及异常功能连接与 T2DM 患者临床指标                               111-115. DOI: 10.12015/issn.1674-8034.2023.12.019.
                                                                   GAO  Y  J,  SUN  J,  GUO  X,  et  al.  Research  progress  of  resting-state
                                         [37]
           及 MoCA 评分有相关性。LIU 等 发现不同糖代谢                             functional magnetic resonance imaging in the auxiliary diagnosis and
                                                                   early  prognosis  of  bipolar  disorder[J].  Chin  J  Magn  Reson  Imaging,
           状态下和病程中，T2DM患者的脑功能连接可能会出                                2023, 14(12): 111-115. DOI: 10.12015/issn.1674-8034.2023.12.019.
                                                                [6]  HORIEN C, CONSTABLE R T, ROSS D A. Imaging and reimagining
                                      [38]
           现不同的模式。因此，淦帆等 推测脑功能指标与                                  the  Mind:  fMRI  and  psychiatric  illness[J/OL].  Biol  Psychiatry,  2021,
           T2DM相关检验指标的相关关系是动态变化的，增大                                89(9): e45-e47 [2023-12-18]. https://pubmed.ncbi.nlm.nih.gov/33858592/.
                                                                   DOI: 10.1016/j.biopsych.2021.02.013.
           了捕捉相关性的难度。本研究中纳入的 T2DM 患者                            [7]  贾清, 黄小华, 刘念, 等 . 2型糖尿病认知障碍的静息态脑功能研究进
                                                                   展[J]. 磁共振成像, 2021, 12(10): 89-92. DOI: 10.12015/issn.1674-8034.
           均未发生认知功能障碍，这也可能是本研究未发现                                  2021.10.023.
                                                                   JIA Q, HUANG X H, LIU N, et al. Research progress of resting-state
           相关性的原因之一。                                               brain  functional  network  in  T2DM  patients  with  cognitive  impairment[J].
           3.4 局限性                                                 Chin J Magn Reson Imaging, 2021, 12(10): 89-92. DOI: 10.3760/cma.j.
                                                                   cn115791-20210221-00095.
               本研究尚存不足之处。首先，滑窗法的窗宽设                             [8]  IBRAHIM  B,  SUPPIAH  S,  IBRAHIM  N,  et  al.  Diagnostic  power  of
                                                                   resting-state fMRI for detection of network connectivity in Alzheimer's
           置可能会影响分析结果，窗宽的最优化选择仍有待                                  disease  and  mild  cognitive  impairment: A  systematic  review[J].  Hum
           于进一步研究。其次，dFNC 理论背后的神经生物学                            [9]  Brain Mapp, 2021, 42(9): 2941-2968. DOI: 10.1002/hbm.25369.
                                                                   MATSUI  T,  YAMASHITA  K  I.  Static  and  dynamic  functional
           机制仍有待阐明，限制了对分析结果的深入解读。                                  connectivity  alterations  in  Alzheimer's  disease  and  neuropsychiatric
                                                                   diseases[J]. Brain Connect, 2023, 13(5): 307-314. DOI: 10.1089/brain.2022.
           最后，对治疗药物以及肥胖因素对分析结果的影响                                  0044.
                                                               [10] VALSASINA P, HIDALGO M, FILIPPI M, et al. Characterizing rapid
           仍有待于进一步分析，在后续研究中将把患者治疗                                  fluctuations  of  resting  state  functional  connectivity  in  demyelinating,
           方案和肥胖症等纳入考量，检验研究结果。                                     neurodegenerative,  and  psychiatric  conditions:  From  static  to  time-varying
                                                                   analysis[J/OL].  Front  Neurosci,  2019,  13:  618  [2023-12-18].  https://
                                                                   pubmed.ncbi.nlm.nih.gov/31354402/. DOI: 10.3389/fnins.2019.00618.
                                                               [11] HUTCHISON R M, WOMELSDORF T, ALLEN E A, et al. Dynamic
           4 结论                                                    functional connectivity: promise, issues, and interpretations[J]. Neuroimage.
                                                                   2013, 80: 360-378. DOI: 10.1016/j.neuroimage.2013.05.079.
               综上所述，本研究基于GICA技术，探究认知功能                         [12] CALHOUN VD, DE LACY N. Ten key observations on the analysis of
           正 常 的 T2DM 动 态 脑 网 络 连 接 改 变 。 结 果 发 现                  resting-state  functional  MR  imaging  data  using  independent  component
                                                                   analysis[J].  Neuroimaging  Clin  N  Am,  2017,  27(4):  561-579.  DOI:
           T2DM 患者在特定连接模式的平均滞留时间和时间                                10.1016/j.nic.2017.06.012.
                                                               [13] DAUTRICOURT  S,  GONNEAUD  J,  LANDEAU  B,  et  al.  Dynamic
           分数显著高于健康对照，并且视觉、基底节、突显网络                                functional  connectivity  patterns  associated  with  dementia  risk[J/OL].
           间的功能连接存在异常改变，这为理解T2DM相关认                                Alzheimers  Res  Ther,  2022,  14(1):  72  [2023-12-18].  https://pubmed.
                                                                   ncbi.nlm.nih.gov/35606867/. DOI: 10.1186/s13195-022-01006-7.
           知损伤发生的神经病理机制提供了一定的借鉴意义。                             [14] CATTARINUSSI  G,  DI  GIORGIO  A,  MORETTI  F,  et  al.  Dynamic
                                                                   functional connectivity in schizophrenia and bipolar disorder: A review
               作者利益冲突声明：全体作者均声明无利益冲突。                              of  the  evidence  and  associations  with  psychopathological  features[J/OL].
                                                                   Prog  Neuropsychopharmacol  Biol  Psychiatry,  2023,  127:  110827
               作者贡献声明：王梅云设计本研究的方案，对稿                               [2023-12-18]. https://pubmed.ncbi.nlm.nih.gov/37473954/. DOI: 10.1016/
                                                                   j.pnpbp.2023.110827.
           件重要的内容进行了修改；张戈实施本研究的试验                              [15] YANG  W,  WANG  Y,  QIN  W,  et  al.  Abnormal  dynamic  functional
           方案，获取、分析并解释本研究的数据，起草并撰写                                 network  connectivity  in  first-episode,  drug-naïve  patients  with  major
                                                                   depressive  disorder[J].  J  Affect  Disord,  2022,  319:  336-343.  DOI:
           稿件；张艳伟参与本研究试验方案的设计，对稿件的                                 10.1016/j.jad.2022.08.072.
                                                               [16] YUE  X,  ZHANG  G,  LI  X,  et  al. Abnormal  dynamic  functional  network
           重要内容进行了修改，获得了联勤保障部队第 980医                               connectivity  in  adults  with  autism  spectrum  disorder[J].  Clin  Neuroradiol,
                                                                   2022, 32(4): 1087-1096. DOI: 10.1007/s00062-022-01173-y.
           院孵育计划项目资助；刘太元获取、分析本研究的数                             [17] LV  H,  WANG  Z,  TONG  E,  et  al.  Resting-state  functional  MRI:
           据，对稿件的重要内容进行了修改，获得了河南省医                                 Everything that nonexperts have always wanted to know[J]. AJNR Am
                                                                   J Neuroradiol, 2018, 39(8): 1390-1399. DOI: 10.3174/ajnr.A5527.
           学科技攻关计划项目资助；王涵、魏巍获取、分析本                             [18] ALLEN E A, ERHARDT E B, DAMARAJU E, et al. A baseline for the
                                                                   multivariate  comparison  of  resting-state  networks[J/OL].  Front  Syst
           研究的数据，对稿件的重要内容进行了修改；全体作                                 Neurosci,  2011,  5:  2  [2023-12-18].  https://pubmed.ncbi.nlm.nih.gov/
           者都同意发表最后的修改稿，同意对本研究的所有                                  21442040/. DOI: 10.3389/fnsys.2011.00002.
                                                               [19] FU  Z,  DU  Y,  CALHOUN  V  D.  The  Dynamic  Functional  Network
           方面负责，确保本研究的准确性和诚信。                                      Connectivity Analysis  Framework.  Engineering  (Beijing).  2019,  5(2):
                                                                   190-193. DOI: 10.1016/j.eng.2018.10.001.
                                                               [20] FU Z, TU Y, DI X, et al. Transient increased thalamic-sensory connectivity
                                                                   and decreased whole-brain dynamism in autism[J]. Neuroimage, 2019, 190:
           参考文献[References]                                        191-204. DOI: 10.1016/j.neuroimage.2018.06.003.
           [1]  CLOETE  L.  Diabetes  mellitus:  an  overview  of  the  types,  symptoms,   [21] ALLEN  EA,  DAMARAJU  E,  PLIS  SM,  et  al.  Tracking  whole-brain
              complications and management[J]. Nurs Stand, 2022, 37(1): 61-66. DOI:   connectivity  dynamics  in  the  resting  state[J].  Cereb  Cortex,  2014,
              10.7748/ns.2021.e11709.                              24(3): 663-676. DOI: 10.1093/cercor/bhs352.
           [2]  中华医学会糖尿病学分会 . 中国 2 型糖尿病防治指南(2020 年版)[J].       [22] ESPINOZA F A, ANDERSON N E, VERGARA V M, et al. Resting-state
              中华糖尿病杂志, 2021, 13(4): 315-409. DOI: 10.3760/cma.j.cn115791-  fMRI  dynamic  functional  network  connectivity  and  associations  with
              20210221-00095.                                      psychopathy traits[J/OL]. Neuroimage Clin, 2019, 24: 101970 [2023-12-18].
              Chinese Diabetes Society. Guidline for the prevention and treatment of type   https://pubmed.ncbi.nlm.nih.gov/31473543/. DOI: 10.1016/j.nicl.2019.
              2  diabetes  mellitus  in  China  (2020  edition) [J].  Chin  J  Diabetes  Mellitus,   101970.
              2021, 23(4): 314-409. DOI: 10.3760/cma.j.cn115791-20210221-00095.  [23] ESPINOZA  FA,  LIU  J,  CIAROCHI  J,  et  al.  Dynamic  functional
           [3]  SRIKANTH  V,  SINCLAIR  A  J,  HILL-BRIGGS  F,  et  al.  Type  2   network connectivity in Huntington's disease and its associations with
              diabetes  and  cognitive  dysfunction-towards  effective  management  of   motor  and  cognitive  measures[J].  Hum  Brain  Mapp,  2019,  40(6):
              both  comorbidities[J].  Lancet  Diabetes  Endocrinol,  2020,  8(6):  535-545.   1955-1968. DOI: 10.1002/hbm.24504.
              DOI: 10.1016/S2213-8587(20)30118-2.                                                 （下转第69页）

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