Page 53 - 磁共振成像2024年7期电子刊

临床研究｜｜Clinical Articles 磁共振成像 2024年7月第15卷第7期 Chin J Magn Reson Imaging, Jul, 2024, Vol. 15, No. 7

基于群组独立成分分析的2型糖尿病患者

动态脑功能网络连接特征分析研究

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张戈 ，张艳伟 ，刘太元 ，王涵 ，魏巍 ，王梅云 1*
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作者单位 1.河南省人民医院影像科，郑州 450003；2.白求恩国际和平医院（联勤保障部队第980医院）放射诊断科，石家庄 050051
* 通信作者 王梅云，E-mail: mywang@zzu.edu.cn
中图分类号 R445.2；R781.64 文献标识码 A DOI 10.12015/issn.1674-8034.2024.07.008
本文引用格式 张戈, 张艳伟, 刘太元, 等. 基于群组独立成分分析的2型糖尿病患者动态脑功能网络连接特征分析研究[J]. 磁共振
成像, 2024, 15(7): 46-50, 69.
[摘要] 目的 通过动态脑网络特征分析的方法探索2型糖尿病（type 2 diabetes mellitus, T2DM）认知功能正常患者的自发神经
活动改变。材料与方法 本研究前瞻性纳入 39名认知功能正常的 T2DM 患者及年龄、性别、文化程度与 T2DM 患者相匹配的同
等数量的健康对照者，两组患者均行 3.0 T静息态脑功能磁共振扫描。图像经预处理后，使用 GIFT工具包进行动态脑网络分析，
提取动态功能连接指标并比较组间差异，并分析以上指标与 T2DM 患者临床指标的相关性。结果 与对照组相比，T2DM 患者
在 state5 中的平均滞留时间和时间分数显著高于健康对照组（P=0.014、0.039），并且初级视觉网络和突显网络的功能连接显著
升高（P=0.027），空间视觉网络和基底节网络的功能连接显著降低（P=0.044），然而上述动态脑功能指标与空腹血糖值等临床
指标无显著相关性（P 均>0.05）。结论 认知功能正常 T2DM 患者的动态脑功能连接模式以及视觉相关网络的动态功能连接存
在异常改变，这为理解T2DM相关神经病理机制提供了一定的借鉴意义。
[关键词] 2型糖尿病；认知障碍；静息态功能磁共振成像；磁共振成像；独立成分分析；动态功能网络连接

Analysis of dynamic brain function network connectivity in type 2 diabetes patients based on
group independent component analysis

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ZHANG Ge , ZHANG Yanwei , LIU Taiyuan , WANG Han , WEI Wei , WANG Meiyun 1*
1 Department of Radiology, Henan Provincial People's Hospital, Zhengzhou 450003, China; Department of Radiology Diagnosis,
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Bethune International Peace Hospital (980th hospital of Joint Logistic Support Force), Shijiazhuang 050051, China
* Correspondence to WANG M Y, E-mail: mywang@zzu.edu.cn
Received 18 Dec 2023, Accepted 11 Jul 2024; DOI 10.12015/issn.1674-8034.2024.07.008
ACKNOWLEDGMENTS Joint Logistic Support Force 980th Hospital Incubation Project (No. FYJHQN202304); Henan Medical
Science and Technology Research Plan (No. LHGJ20210028).
Cite this article as ZHANG G, ZHANG Y W, LIU T Y, et al. Analysis of dynamic brain function network connectivity in type 2
diabetes patients based on group independent component analysis[J]. Chin J Magn Reson Imaging, 2024, 15(7): 46-50, 69.
Abstract Objective: To explore the changes of spontaneous neural activity in type 2 diabetes mellitus (T2DM) patients without
cognitive impairment based on dynamic functional network connectivity (dFNC) analysis. Materials and Methods: Thirty-nine T2DM
patients without cognitive impairment and 39 age, sex and education matched healthy controls were included in this study. Both groups
underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan in a 3.0 T MRI scanner. After being preprocessed, the
functional images were further managed using GIFT package to perform dFNC analyzing and statistical comparisons. Correlations
between measurements of dFNC and clinical characteristics were also investigated. Results: T2DM patients had significantly higher
mean dewell time (P=0.014) and fraction time (P=0.039) in state5, and significantly higher functional connectivity between the primary
visual network and the salient network (P=0.027), and significantly lower functional connections in the visuospatial network and the
basal ganglia network (all P=0.044). However, the aforementioned dynamic brain function indicators show no significant correlation
with clinical indicators such as fasting blood glucose levels (all P>0.05). Conclusions: There were abnormal changes in dFNC patterns
and connectivity of vision-related networks in T2DM patients without cognitive impairment, which might provide more information to
help understand neuropathological mechanism in diabetic brains.
Key words type 2 diabetes mellitus; cognitive impairment; resting-state functional magnetic resonance imaging; magnetic resonance
imaging; independent component analysis; dynamic brain network connectivity

0 引言 是认知障碍发生乃至痴呆的重要危险因素 [3-4] 。然
糖尿病是一组以胰岛素绝对或相对分泌不足和 而，T2DM相关认知障碍发生的神经生理学机制仍尚
（或）胰岛素利用障碍引起的代谢性紊乱疾病，主要 未完全阐明。
包 括 1 型 糖 尿 病 和 2 型 糖 尿 病（type 2 diabetes 静息态脑功能磁共振成像（resting-state functional
mellitus, T2DM）两种类型，其中 T2DM占比达到 90% magnetic resonance imaging, rs-fMRI）方法是既往研
[1]
以上 。近 10 多年来，我国糖尿病人群迅速增加，患 究揭示 T2DM 相关脑功能异常的主要手段，可在脑
[2]
者人数已达到 1.4亿人 。流行病学研究表明，T2DM 结构损伤发生前早期检测特定脑区功能连接或自发

收稿日期 2023-12-18 接受日期 2024-07-11
基金项目 联勤保障部队第九八〇医院孵育计划项目（编号：FYJHQN202304）；河南省医学科技攻关计划项目（编号：LHGJ20210028）

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