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临床研究｜｜Clinical Articles              磁共振成像  2024年7月第15卷第7期  Chin J Magn Reson Imaging, Jul, 2024, Vol. 15, No. 7


           比率低频振幅技术在延年九转法治疗慢性疲劳

           综合征伴焦虑抑郁中的应用价值

                                          2*
                                   1
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                       1
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           谢芳芳 ，顾元嘉 ，管翀 ，谢超群 ，许家佗 ，姚斐           1*
           作者单位  1.上海中医药大学针灸推拿学院，上海 201203；2.上海中医药大学中医学院，上海 201203
           通信作者  许家佗，E-mail: xjt@fudan.edu.cn；姚斐，E-mail: doctoryaofei@126.com
           *
           中图分类号  R445.2；R749  文献标识码  A  DOI  10.12015/issn.1674-8034.2024.07.010
           本文引用格式  谢芳芳, 顾元嘉, 管翀, 等 . 比率低频振幅技术在延年九转法治疗慢性疲劳综合征伴焦虑抑郁中的应用价值[J]. 磁
           共振成像, 2024, 15(7): 58-63.
           [摘要]  目的 比较延年九转法与认知行为治疗后，慢性疲劳综合征（chronic fatigue syndrome, CFS）伴焦虑与抑郁症状患者
           的大脑静息态下功能MRI（functional MRI, fMRI）比率低频振幅（fractional amplitude of low-frequency fluctuations, fALFF）的脑
           区差异改变情况。材料与方法 将 30 例 CFS 患者随机分为延年九转法组和认知行为组，治疗 12 周后进行 fMRI 检测，采用
           Pearson相关分析探索 fALFF变化与焦虑抑郁量表（Hospital Anxiety and Depression Scale, HADS）的线性相关性。结果 与认知
           行为组相比，延年九转法组 fALFF减弱的脑区有左侧梭状回、左侧枕上回、左侧角回；增强的脑区有右侧颞中回。焦虑症状分
           值与梭状回（r=0.525，P=0.044）和枕上回（r=0.559，P=0.030）的 fALFF 平均值呈正相关，抑郁症状分值与梭状回（r=0.542，
           P=0.037）的 fALFF 平均值呈正相关（P<0.05）。结论 延年九转法可能通过梭状回、枕上回、角回、颞中回神经活动水平强弱
           客观反映CFS患者焦虑与抑郁症状。
           [关键词]  慢性疲劳综合征；焦虑抑郁；延年九转法；气功；静息态功能磁共振成像；磁共振成像；比率低频振幅；神经元
           活动

           The application value of fractional amplitude of low frequency fluctuation in the treatment of
           chronic fatigue syndrome with anxiety depression by Prolong Life With Nine Turn method
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           XIE Fangfang , GU Yuanjia , GUAN Chong , XIE Chaoqun , XU Jiatuo , YAO Fei 1*
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           1 School  of  Acupuncture  and  Massage,  Shanghai  University  of  Traditional  Chinese  Medicine,  Shanghai  201203,  China;  College  of
                                                                                                      2
           Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
           * Correspondence to  XU J T, E-mail: xjt@fudan.edu.cn; YAO F, E-mail: doctoryaofei@126.com
           Received  3 Dec 2023, Accepted  5 Jun 2024; DOI  10.12015/issn.1674-8034.2024.07.010
           ACKNOWLEDGMENTS  National Natural Science Foundation of China (No. 82105038, 82374610).
           Cite this article as  XIE F F, GU Y J, GUAN C, et al. The application value of fractional amplitude of low frequency fluctuation in the
           treatment of chronic fatigue syndrome with anxiety depression by Prolong Life With Nine Turn method[J]. Chin J Magn Reson Imaging,
           2024, 15(7): 58-63.
           Abstract   Objective:  To  compare  the  regional  differences  in  resting-state  functional  MRI  (fMRI)  fractional  amplitude  of  low-frequency
           fluctuations  (fALFF)  in  the  brains  of  patients  with  chronic  fatigue  syndrome  (CFS)  accompanied  by  anxiety  and  depressive  symptoms  after
           treatment with the Prolong Life With Nine Turn (PLWNT) method versus cognitive-behavioral therapy (CBT). Materials and Methods: Thirty
           CFS patients were randomly assigned to either the PLWNT group or the cognitive behavioral therapy (CBT) group. FMRI was conducted
           after 12 weeks of treatment, and Pearson correlation analysis was employed to examine the linear relationship between changes in fALFF
           and the Hospital Anxiety and Depression Scale (HADS). Results: Compared to the control group, fALFF decreased in the left fusiform
           gyrus, left suproccipital gyrus, and left angular gyrus. The right medial temporal gyrus showed increased brain activity. Anxiety symptom
           scores  positively  correlated  with  fALFF  values  in  the  fusiform  gyrus  (r=0.525,  P=0.044)  and  occipital  gyrus  (r=0.559,  P=0.030),  while
           depression symptom scores positively correlated with fALFF values in the fusiform gyrus (r=0.542, P=0.037) (P<0.05). Conclusions: The
           PLWNT may objectively reflect anxiety and depression symptoms in CFS patients through neural activity levels in the fusiform gyrus, occipital
           gyrus, angular gyrus, and middle temporal gyrus.
           Key words  chronic fatigue syndrome; anxiety and depression; Prolong Life With Nine Turn Method; Qigong; resting-state functional
           magnetic resonance imaging; magnetic resonance imaging; fractional amplitude of low frequency fluctuation; neuronal activity


                                                                            [3]
           0 引言                                                户或卧床不起 。CFS 焦虑抑郁症状在很大程度上
               慢性疲劳综合征（chronic fatigue syndrome, CFS）          被忽视，流行病学调查显示，约 32%~57% 的 CFS 患
           是一种使人衰弱的多系统疾病，通常以严重疲劳、情                             者伴有不同程度的焦虑抑郁症状                 [4-5] 。CFS 每年的治
                                                                                              [6]
           绪障碍、自主神经功能障碍和运动后不适为特征，严                             疗费用预估为 180 亿至 240 亿美元 ，给家人、医疗服
           重影响日常生活活动 。CFS 在全球范围内患病人                            务机构和社会造成了严重的经济负担。传统气功是
                              [1]
                                 [2]
           数约为 1700 万至 2400 万 ，大多数 CFS 患者无法完                   被国际慢性疲劳综合征协会出版的临床手册推荐为
                                                                                                  [7]
           全恢复到病前功能，三分之一的患者严重到足不出                              缓解 CFS 的一种有效补充替代疗方法 。延年九转
           收稿日期  2023-12-03  接受日期  2024-06-05
           基金项目  国家自然科学基金项目（编号：82105038、82374610）

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