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磁共振成像 2024年7月第15卷第7期 Chin J Magn Reson Imaging, Jul, 2024, Vol. 15, No. 7 临床研究｜｜Clinical Articles

中等强度有氧运动对女大学生大脑结构影响的

VBM研究

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1, 2
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史冀龙 ，王君 ，于勇 ，薛姣 ，侯莉娟 1*
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作者单位 1.北京师范大学体育与运动学院，北京 100875；2.上海体育大学心理学院，上海 200438；3.北京师范大学认知神经科学
与学习国家重点实验室，北京 100875；4.北京师范大学中国基础教育质量监测协同创新中心，北京 100875
* 通信作者 侯莉娟，E-mail: houlj@bnu.edu.cn
中图分类号 R445.2；R455 文献标识码 A DOI 10.12015/issn.1674-8034.2024.07.015
本文引用格式 史冀龙, 王君, 于勇, 等 . 中等强度有氧运动对女大学生大脑结构影响的 VBM 研究[J]. 磁共振成像, 2024, 15(7):
87-93.

[摘要] 目的 采用基于体素的形态学测量（voxel-based morphometry, VBM）方法探讨中等强度有氧运动对高低有氧能力女大
学生大脑灰质结构可塑性的影响。材料与方法 纳入 24名健康女大学生为研究对象，按照最大摄氧量分为高低有氧组，对其进
行16周规律性中等强度有氧运动干预。在有氧运动干预前后采集T1WI脑结构像数据，以VBM方法比较中等强度有氧运动干预
前后，高低有氧组女大学生大脑灰质体积变化。结果 重复测量方差分析显示，经过中等强度有氧运动干预后，高低有氧能力
女大学生的最大摄氧量均显著提升（P<0.001）；低有氧能力女大学生在双侧颞上回/颞中回/缘上回/顶下小叶，右侧额中回/前扣
带回/额内侧回灰质体积显著减小（GRF校正，体素水平P<0.001，团块水平P<0.01）；高有氧能力女大学生在双侧额内侧回/前扣
带回、左侧额中回/额下回、左侧颞上回/颞中回，右侧额上回/额下回/脑岛，右侧颞中回/颞下回灰质体积显著减小（GRF 校正，
体素水平 P<0.001，团块水平 P<0.01）。结论 中等强度有氧运动引起的女大学生大脑灰质结构的变化可能是运动引起大脑可塑
性改变的机制之一，且与受试者的最大摄氧量存在一定的相关性。
[关键词] 中等强度有氧运动；基于体素的形态学；磁共振成像；有氧能力；脑可塑性
A VBM study on the effect of moderate-intensity aerobic exercise on the brain structure of female
college students

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SHI Jilong , WANG Jun , YU Yong , XUE Jiao , HOU Lijuan 1*
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1 College of Physical Education and Sports, Beijing Normal University, Beijing 100875, China; School of Psychology, Shanghai University of
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Sport, Shanghai 200438, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875,
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China; Collaborative Innovation Center of Assessment toward Basic Education Quality, Beijing Normal University, Beijing 100875, China
* Correspondence to HOU L J, E-mail: houlj@bnu.edu.cn
Received 18 Dec 2023, Accepted 12 Jul 2024; DOI 10.12015/issn.1674-8034.2024.07.015
ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 31971095).
Cite this article as SHI J L, WANG J, YU Y, et al. A VBM study on the effect of moderate-intensity aerobic exercise on the brain
structure of female college students[J]. Chin J Magn Reson Imaging, 2024, 15(7): 87-93.
Abstract Objective: To investigate the effects of moderate-intensity aerobic exercise on the plasticity of gray matter in female college
students with high and low aerobic capacity by voxel-based morphometry (VBM). Materials and Methods: Healthy female college
students were included in the study and divided into high and low aerobic capacity groups based on their maximum oxygen uptake
(VO 2max ). They underwent a 16-week regimen of moderate-intensity aerobic exercise intervention. T1-weighted brain structural images
were collected before and after the aerobic exercise intervention, and changes in brain gray matter volume in the high and low aerobic
capacity groups were compared using voxel-based morphometry (VBM). Results: Repeated measures ANOVA showed that after the
intervention of moderate-intensity aerobic exercise, there was a significant increase in the VO 2max among both high and low aerobic
capacity female college students (P<0.001). In female students with low aerobic capacity, there was a significant reduction in gray matter
volume in the bilateral superior temporal gyrus/middle temporal gyrus/supramarginal gyrus/inferior parietal lobule, and right medial
frontal gyrus/anterior cingulate gyrus/medial frontal gyrus (GRF corrected, voxel-level P<0.001, cluster-level P<0.01). In high aerobic
capacity female students, significant reductions in gray matter volume were observed in the bilateral medial frontal gyrus/anterior
cingulate gyrus, left medial frontal gyrus/inferior frontal gyrus, left superior temporal gyrus/middle temporal gyrus, right superior frontal
gyrus/inferior frontal gyrus/insula, and right middle temporal gyrus/inferior temporal gyrus (GRF corrected, voxel-level P<0.001,
cluster-level P<0.01). Conclusions: changes in gray matter structure in female college students induced by moderate-intensity aerobic
exercise may be one of the mechanisms of brain plasticity induced by exercise. Moreover, these changes were correlated with the VO 2max
of the participants.
Key words moderate intensity aerobic exercise; voxel-based morphometry; magnetic resonance imaging; aerobic capacity; brain plasticity

[1]
0 引言 影响，并贯穿人的整个生命周期 。有氧运动作为运
体育活动是保持身体及心理健康的最有效方式 动干预的主要手段之一，可以延缓老年痴呆，降低帕
之一，对人类大脑结构、功能、认知能力都有积极的 金森病、卒中等疾病的发生率 [2-4] 。此外，有研究表明

收稿日期 2023-12-18 接受日期 2024-07-12
基金项目 国家自然科学基金项目（编号：31971095）

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