Page 34 - 磁共振成像2024年7期电子刊

磁共振成像 2024年7月第15卷第7期 Chin J Magn Reson Imaging, Jul, 2024, Vol. 15, No. 7 特别关注｜｜Special Focus
PET/MR专题｜｜临床研究
18 F-FDG PET/MR代谢及扩散参数对非小细胞肺癌

患者预后评估价值研究

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周一航 ，姜涵 ，孟楠 ，王鑫惠 ，刘雪 ，袁健闵 ，杨阳 ，王哲 ，王梅云 1, 2, 3*
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作者单位 1.新乡医学院河南省人民医院放射科，郑州 463599；2.河南省科学院医学科学与工程综合研究所脑科学与类脑智能技
术实验室，郑州 450046；3.河南省人民医院&郑州大学人民医院放射科，郑州 463599；4.上海联影医疗科技股份有限公司中央研究
院，上海 201807；5.北京联影智能影像技术研究院，北京 100094
* 通信作者 王梅云，E-mail: mywang@ha.edu.cn
中图分类号 R445.2；R734.2 文献标识码 A DOI 10.12015/issn.1674-8034.2024.07.005
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本文引用格式 周一航, 姜涵, 孟楠, 等 . F-FDG PET/MR 代谢及扩散参数对非小细胞肺癌患者预后评估价值研究[J]. 磁共振成
像, 2024, 15(7): 27-31.
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[摘要] 目的 探讨 F-氟代脱氧葡萄糖（ F-fluorodeoxyglucose, F-FDG）正电子发射断层扫描/磁共振（positron emission
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tomography/magnetic resonance, PET/MR）成像代谢参数及扩散参数对非小细胞肺癌（non-small cell lung cancer, NSCLC）患者预
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后评估的价值。材料与方法 前瞻性纳入 CT 检查怀疑有肺部占位性病变后进行 3.0 T 胸部 F-FDG PET/MR 混合扫描的患者
48 例，分析扫描图像的最大标准摄取值 （maximum standardized uptake value, SUV ） 和表观扩散系数 （apparent diffusion
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coefficient, ADC）与临床可能预后因素的关系。用 Kaplan-Meier 法、Log-rank 检验及单因素和多因素 Cox 回归分析代谢参数
SUV max 和 ADC 与无进展生存期（progression-free survival, PFS）和总生存期（overall survival, OS）的关系。结果 48 例 NSCLC
患者的 SUV 和 ADC的中位数分别为 5.87（3.92, 9.66）和 1.41（1.28, 1.57）。单因素分析显示，是否手术[HR=6.704，95% 置信
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区间（confidence interval, CI）为 1.422~31.614，P=0.016；HR=7.174，95% CI 为 1.486~34.626，P=0.014]、SUV max （HR=1.170，
95% CI 为 1.010~1.355，P=0.036；HR=1.173，95% CI 为 1.010~1.360，P=0.035）及 ADC（HR=0.010，95% CI 为 0.000~0.232，
P=0.004；HR=0.006，95% CI 为 0.000~0.156，P=0.002）是 NSCLC 患者 PFS 和 OS 的影响因素。多因素分析显示，ADC（HR=
0.012，95% CI 为 0.000~0.386，P=0.012；HR=0.008，95% CI 为 0.000~0.298，P=0.009）是影响 NSCLC 患者 PFS 和 OS 的独立危
险因素。结论 SUV max 和 ADC都是 NSCLC患者预后的影响因素，并且，ADC可能比 SUV max 更有助于预测 NSCLC患者的预后，
18 F-FDG PET/MR代谢参数及扩散参数对NSCLC患者预后评估具有一定的价值。
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[关键词] 非小细胞肺癌；正电子发射断层成像/磁共振成像； F-氟代脱氧葡萄糖；预后评估；磁共振成像；扩散加权成像
Prognostic evaluation value of F-FDG PET/MR metabolic and diffusion parameters in non-small cell
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lung cancer patients
ZHOU Yihang , JIANG Han , MENG Nan , WANG Xinhui , LIU Xue , YUAN Jianmin , YANG Yang , WANG Zhe ,
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WANG Meiyun 1, 2, 3*
1 Radiology Department, Xinxiang Medical University Henan Provincial People's Hospital, Zhengzhou 463599, China; Laboratory of
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Brain Science and Brain-Like Intelligence Technology, Institute for Integrated Medical Science and Engineering, Henan Academy of
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Sciences, Zhengzhou 450046, China; Radiology Department, Henan Provincial People's Hospital & Zhengzhou University People's
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Hospital, Zhengzhou 463599, China; Central Research Institute, United Imaging Healthcare Group, Shanghai 201807, China; Beijing
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United Imaging Research Institute of Intelligent Imaging, United Imaging Healthcare Group, Beijing 100094, China
* Correspondence to WANG M Y, E-mail: mywang@ha.edu.cn
Received 2 Sep 2023, Accepted 22 Mar 2024; DOI 10.12015/issn.1674-8034.2024.07.005
ACKNOWLEDGMENTS Henan Medical Science and Technology Research Program (No. LHGJ20210001).
Cite this article as ZHOU Y H, JIANG H, MENG N, et al. Prognostic evaluation value of F-FDG PET/MR metabolic and diffusion
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parameters in non-small cell lung cancer patients[J]. Chin J Magn Reson Imaging, 2024, 15(7): 27-31.
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Abstract Objective: To investigate the value of F-fluorodeoxyglucose ( F-FDG) positron emission tomography magnetic resonance
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(PET/MR) metabolic parameters and diffusion parameters in the prognosis of patients with non-small cell lung cancer (NSCLC).
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Materials and Methods: Prospective 3.0 T chest F-FDG PET/MR hybrid scans were performed in patients suspected of having lung
space occupying lesions by CT examination in Henan Provincial People's Hospital from July 8, 2020 to July 29, 2021. The relationship
between the maximum standardized uptake value (SUV ) and apparent diffusion coefficient (ADC) of scanned images and clinical
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possible prognostic factors was analyzed. Kaplan Meier method, log rank test and univariate and multivariate Cox regression were used
to analyze the relationship between metabolic parameter SUV and diffusion parameter ADC and overall survival (OS) and progression
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free survival (PFS). Results: The median SUV and ADC of 48 NSCLC patients were 5.87 (3.92, 9.66) and 1.41 (1.28, 1.57),
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respectively. Univariate analysis showed that whether surgery [HR=6.704, 95% confidence interval (CI): 1.422-31.614, P=0.016; HR=
7.174, 95% CI: 1.486-34.626, P=0.014], SUV (HR=1.170, 95% CI: 1.010-1.355, P=0.036; HR=1.173, 95% CI: 1.010-1.360, P=0.035)
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and ADC (HR=0.010, 95% CI: 0.000-0.232, P=0.004; HR=0.006, 95% CI: 0. 000-0.156, P=0.002) were the influencing factors of PFS
and OS in NSCLC patients. Multivariate analysis showed that ADC (HR=0.012, 95% CI: 0.000-0.386, P=0.012; HR=0.008, 95% CI:
0.000-0.298, P=0.009) was an independent risk factor for PFS and OS in NSCLC patients. Conclusions: Both SUV and ADC are
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prognostic factors for NSCLC patients, and ADC may be more helpful in predicting the prognosis of NSCLC patients than SUV .
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18 F-FDG PET/MR metabolic parameters and diffusion parameters have certain value for the prognosis evaluation of NSCLC patients.
收稿日期 2023-09-02 接受日期 2024-03-22
基金项目 河南省医学科技攻关计划项目（编号：LHGJ20210001）
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