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磁共振成像  2024年7月第15卷第7期  Chin J Magn Reson Imaging, Jul, 2024, Vol. 15, No. 7   临床研究｜｜Clinical Articles


              阿斯伯格综合征与高功能孤独症在脑网络上的

              差异：静息态fMRI的图论研究

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              罗致 ，岳希鹏 ，高子涵 ，魏巍 ，白岩 ，王梅云             1, 2, 3*
                          1, 2
                                  1, 2
              作者单位  1. 郑州大学人民医院影像科，郑州 463599；2. 河南省人民医院影像科，郑州 463599；3. 河南省科学院生物医学研究所，
              郑州 450046
              * 通信作者  王梅云，E-mail: mywang@zzu.edu.cn
              中图分类号  R445.2；R748  文献标识码  A  DOI  10.12015/issn.1674-8034.2024.07.007
              本文引用格式  罗致, 岳希鹏, 高子涵, 等 . 阿斯伯格综合征与高功能孤独症在脑网络上的差异：静息态 fMRI的图论研究[J]. 磁共
              振成像, 2024, 15(7): 39-45.

              [摘要]  目的 关于阿斯伯格综合征（Asperger's syndrome, AS）和高功能孤独症（high functioning autism, HFA）之间的差异的
              争论已经持续了数十年，本研究拟采用静息态功能磁共振成像图论的方法来探索这两种疾病在脑功能上的差异。材料与方法
              使用美国孤独症脑成像交换数据库Ⅰ（Autism Brain Imaging Data Exchange, ABIDEI）的影像数据，其中包括 AS 患者（n=55）
              和 HFA患者（n=53）的静息态功能磁共振成像数据。对两组影像数据进行处理，并计算出两组的脑网络图论参数。使用两样本
              t检验比较两组间的脑网络图论参数，并进行事后检验（Bonferroni校正）。使用偏相关分析分别探索两组中有显著差异的图论指
              标与临床数据的相关性。结果 AS 组和 HFA 组在右颞上回的节点效率（P=0.016）、右额中回的节点聚类系数（P=0.044）等多
              个脑区的多个图论指标分别存在显著差异。这些脑区涉及社会、共情、语言和认知功能。此外，AS组患者在双侧脑岛的节点局
              部效率（nodal local efficiency, NLE）与孤独症诊断观察量表评分呈负相关（左脑岛：r=−0.366，P=0.033；右脑岛：r=−0.412，
              P=0.016）。结论 本研究结果可能为不同类型孤独症谱系障碍的脑功能机制提供新的思路和见解，从而有助于揭示孤独症不同
              亚型诊断和治疗的特异性。
              [关键词]  孤独症谱系障碍；高功能孤独症；阿斯伯格综合征；功能磁共振成像；磁共振成像；图论；脑网络
              The differences between Asperger's syndrome and high functioning autism in brain network: A
              resting-state fMRI graph theory study

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              LUO Zhi , YUE Xipeng , GAO Zihan , WEI Wei , BAI Yan , WANG Meiyun 1, 2, 3*
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              1 Department  of  Medical  Imaging,  People's  Hospital  of  Zhengzhou  University,  Zhengzhou  463599,  China;  Department  of  Medical
              Imaging, Henan Province People's Hospital, Zhengzhou 463599, China;  Institute of Biomedical Sciences, Henan Academy of Sciences,
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              Zhengzhou 450046, China
              * Correspondence to  WANG M Y, E-mail: mywang@zzu.edu.cn
              Received  15 Dec 2023, Accepted  25 Jun 2024; DOI  10.12015/issn.1674-8034.2024.07.007
              ACKNOWLEDGMENTS  Key Project of National Key Research and Development Plan (No. 2023YFC2414200); National Natural
              Science Foundation of China (No. 82371934).
              Cite this article as  LUO Z, YUE X P, GAO Z H, et al. The differences between Asperger's syndrome and high functioning autism in
              brain network: A resting-state fMRI graph theory study[J]. Chin J Magn Reson Imaging, 2024, 15(7): 39-45.
              Abstract  Objective: The debate about the differences between Asperger's syndrome (AS) and high functioning autism (HFA) has been
              ongoing for decades. Many previous studies have explored the differences between them from the perspective of cognitive psychology,
              but few studies have explored them from the perspective of functional brain imaging. In this study, we intend to use graph theory to
              explore the differences in brain function between these two diseases. Materials and Methods: Imaging data from the American Autism
              Brain Imaging Exchange Database Ⅰ (ABIDEI) were used, including resting fMRI data from patients with AS (n=55) and HFA (n=53).
              The two groups of image data were preprocessed, and the brain network graph theory parameters of the two groups were calculated. The
              two  sample  t  test  was  used  to  compare  the  brain  network  graph  theory  parameters  between  the  two  groups,  and  a  post  hoc  test
              (Bonferroni's  correction)  was  performed.  Partial  correlation  analysis  was  used  to  investigate  the  correlation  between  graph  theory
              indicators with significant differences and clinical data in the two groups. Results: There were significant differences in the graph theory
              indexes of right superior temporal gyrus (P=0.016) and right middle frontal gyrus (P=0.044) between AS group and HFA group. These
              brain regions are involved in social, empathy, language and cognitive functions. In addition, nodal local efficiency (NLE) was negatively
              correlated with Autism Diagnostic Observation Schedule (ADOS) score in AS group (left insula: r=−0.366, P=0.033; right insula: r=
              − 0.412,  P=0.016).  Conclusions:  The  results  of  this  study  may  provide  new  ideas  and  insights  into  the  brain  function  mechanism  of
              different types of autism and help to reveal the specificity of diagnosis and treatment of different subtypes of autism.
              Key words  autism spectrum disorder; high functioning autism; Asperger's syndrome; functional magnetic resonance imaging; magnetic
              resonance imaging; graph theory; brain network


              0 引言                                                 是一类神经发育障碍疾病，其特征是社交障碍、沟通
                                                                                                [1]
                  孤独症谱系障碍（autism spectrum disorder, ASD）           障碍和刻板重复的行为或兴趣 。孤独症（autistic

              收稿日期  2023-12-15  接受日期  2024-06-25
              基金项目  国家重点研发计划项目（编号：2023YFC2414200）；国家自然科学基金项目（编号：82371934）

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